标题：Subunit treadmilling of microtubules or actin in the presence of cellular barriers: possible conversion of chemical free energy into mechanical work
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：2
页码：490-494
DOI：10.1073/pnas.79.2.490
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Free microtubule or actin filaments, along with the monomeric forms of the protein, hydrolyze GTP or ATP to produce a flux of subunits through the polymer. This flux, called treadmilling, produces no useful work. In the cell, however, these filaments are likely to be constrained between nucleating sites and other barriers that will limit polymer growth. We study here the effects of a small compression of the filaments resulting from polymerization against such barriers. If subunits can still exchange at the two ends, treadmilling will take place here as well. Under these conditions, the filament system can do useful work. The free energy of NTP hydrolysis can be used to transport materials, attached to the filament, against a resisting force. This process can in principle take place at high efficiency and bears a resemblance in a bioenergetic sense to the utilization of ATP free energy in muscle contraction. The same general principles apply to a polymer in which one end is anchored and one end is free.
