标题：Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：6
页码：2003-2007
DOI：10.1073/pnas.79.6.2003
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：This study has assessed the possibility that anti-H-2 receptors are expressed on T-cell precursors prior to their entry into the thymus. Parental strain A thymus was transplanted into either normal or thymectomized (A x B)F1 mice which were then irradiated and reconstituted with strain A bone marrow. The cells repopulating the engrafted strain A thymus were shown to be of donor bone marrow origin. Thus, strain A thymocytes were differentiating within a syngeneic thymus, after exposure to allogeneic strain B major histocompatibility complex (MHC) determinants of the irradiated F1 host. The cells repopulating the engrafted thymus were assessed for their ability to generate alloreactive cytotoxic T lymphocyte responses and were found to be specifically tolerant to allogeneic strain B MHC determinants. This tolerance existed in the absence of detectable suppression and in the absence of detectable strain B MHC determinants intrathymically. These data are most consistent with the concept that precursor T cells express anti-MHC receptors prior to their entry into the thymus and that exposure to MHC determinants prethymically results in their functional inactivation.
