期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：15
页码：4637-4641
DOI：10.1073/pnas.79.15.4637
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We discuss the activation of thin-filament-regulated muscles by calcium ion in terms of a qualitative model based on nearest-neighbor lattice statistics. For the most part, the model takes into account only the essential features of the phenomenon--that there must be an interaction between calcium adsorption to troponin and crossbridge reaction with actin for calcium ion to activate contraction and that the relevant stationary states are nonequilibrium ones. Even so, the model predicts the following features which are seen experimentally but have generally not been considered in previous models: (i) the relative activations of stationary-state isometric force and ATPase are not equal; (ii) in general, neither activation of force nor that of ATPase is proportional to calcium adsorption to the activating sites; and (iii) the slopes of the relations between the activations and the logarithm of the calcium ion concentration generally depend on the necessary interaction between calcium ion adsorption and crossbridge reaction with actin. Thus, these relations show cooperative effects even if these is no interaction between calcium adsorption sites.
