期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：20
页码：6380-6384
DOI：10.1073/pnas.79.20.6380
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have used a crossreactive monoclonal antibody against a mouse neural cell adhesion molecule (N-CAM) to characterize and purify an antigen from embryonic and neonatal human brain. This antigen was identified as human N-CAM according to several criteria, including molecular weight, sialic acid content, amino acid composition, analysis of peptide fragments, reactivity with a variety of anti-CAM antibodies, and activity of the antigen in assays of cell and membrane vesicle aggregation. The findings make feasible an exploration of the possible role of N-CAM in various neurological disorders.
