期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：24
页码：7900-7903
DOI：10.1073/pnas.79.24.7900
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Event-related brain potentials (ERPs) from normal drinkers with and without a family history of alcoholism were compared. Three separate groups of 10 subjects each (5 with and 5 without a family history of alcoholism) ingested either a placebo or ethanol at 0.56 or 0.94 g/kg. In each comparison, ERP components elicited in conjunction with subjects' decisions about task-relevant stimuli were of significantly reduced amplitude in individuals with a family history of alcoholism. Additionally, both the latency of the positive component and reaction times to correctly detected targets were significantly later in individuals with a positive history of alcoholism than in those without such a history. These group differences were apparent both with and without a challenge of alcohol. The data suggest that brain functions are different in individuals at high and low risk for the development of alcoholism (i.e., those with and without a family history of alcoholism, respectively).
