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  • 标题:Ascorbate-quinone interactions: electrochemical, free radical, and cytotoxic properties
  • 本地全文:下载
  • 作者:R Pethig ; P R Gascoyne ; J A McLaughlin
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1983
  • 卷号:80
  • 期号:1
  • 页码:129-132
  • DOI:10.1073/pnas.80.1.129
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Standard midpoint potentials have been determined for p-benzoquinone, methoxy-p-benzoquinone and 2,3-, 2,5-, and 2,6-dimethoxy-p-benzoquinones in aqueous solution. ESR studies have been made of the ascorbate and semiquinone radicals produced when these quinones interact with sodium ascorbate. Direct correlations are found between the electrochemical potentials, generated semiquinone lifetimes, and cytotoxic action in Ehrlich ascites-bearing mice.
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