期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1983
卷号：80
期号：1
页码：247-249
DOI：10.1073/pnas.80.1.247
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The dilute (d) coat color mutation on chromosome 9 is closely associated with an ecotropic murine leukemia virus (MuLV) genome [Jenkins, N.A., Copeland, N.G., Taylor, B.A. & Lee, B.K. (1981) Nature 293, 370-374]. DBA/2J mice homozygous for the reverse mutation to wild type at the dilute locus (d+2J) lack ecotropic virus-specific sequences, suggesting that the dilute mutation was caused by virus integration. In the experiments described here, we analyzed the ecotropic MuLV DNA content of mice that collectively carry 10 different alleles at the agouti coat color locus (of chromosome 2) to determine whether any of these alleles also are associated with ecotropic virus sequences. Of the 10 alleles analyzed, one allele, lethal yellow (Ay), which is carried congeneically and heterozygously on C57BL/6J, 129/Sv, and LT/Sv mice, was closely associated with an ecotropic MuLV provirus. The close association of this provirus with the Ay allele suggests that this mutation also may be caused by virus integration. Furthermore, this association may be useful for molecular cloning and characterizing the many alleles at this locus.
