期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1983
卷号：80
期号：4
页码：1116-1119
DOI：10.1073/pnas.80.4.1116
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A brain peptide with high affinity (420 nM) and marked specificity for brain receptor sites labeled with L-[3H]glutamate has been identified. Amino acid analysis and mass spectroscopy indicate that the peptide is N-acetylaspartylglutamate. The peptide exhibits potent convulsant properties when injected into the rat hippocampus, similar to those produced by the glutamate receptor agonist, quisqualic acid. These findings raise the question whether endogenous brain peptides enriched in acidic amino acids may serve as excitatory neurotransmitters.
