期刊名称:Proceedings of the National Academy of Sciences
印刷版ISSN:0027-8424
电子版ISSN:1091-6490
出版年度:1984
卷号:81
期号:14
页码:4462-4464
DOI:10.1073/pnas.81.14.4462
语种:English
出版社:The National Academy of Sciences of the United States of America
摘要:We have determined the nucleotide sequences of the long terminal repeats of the transposable element gypsy from the cloned mutant alleles sc1, bx3, and bx34e. These mutations are suppressible by the suppressor of Hairy-wing, su(Hw). The long terminal repeats are 482 base pairs long and are highly conserved. In each case, gypsy is inserted into the sequence T-A-C-A-T-A and generates a duplication of the sequence T-A-C-A. This was verified by sequencing an empty site in the wild-type bx gene. Consideration of the sequence of the long terminal repeats and their surroundings limits the possible explanations for the mechanism of mutation by these gypsy insertions and for their suppression by su(Hw).