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  • 标题:Gene overlap and site-specific attenuation of transcription of the viral polymerase L gene of human respiratory syncytial virus
  • 本地全文:下载
  • 作者:P L Collins ; R A Olmsted ; M K Spriggs
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1987
  • 卷号:84
  • 期号:15
  • 页码:5134-5138
  • DOI:10.1073/pnas.84.15.5134
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Sequence analysis of the gene encoding polymerase L protein of respiratory syncytial virus showed that L-gene transcription initiates within its upstream neighbor, the gene encoding the 22-kDa protein 22K. This is an exception to the canonical mode of sequential transcription of nonoverlapping genes described for other nonsegmented negative-strand RNA viruses. As a consequence of the gene overlap, the termination/polyadenylylation signal for the 22K gene is located at nucleotides 56-68 within the L gene. L-gene transcription yielded two RNAs: an abundant, truncated, polyadenylylated transcript resulting from termination at the internal signal and a markedly less abundant large polyadenylylated transcript representing the complete L gene. This result showed that the internal termination/polyadenylylation signal is an attenuator of L-gene transcription.
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