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  • 标题:Duplication of large genomic regions during the evolution of vertebrate homeobox genes
  • 本地全文:下载
  • 作者:K Schughart ; C Kappen ; F H Ruddle
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1989
  • 卷号:86
  • 期号:18
  • 页码:7067-7071
  • DOI:10.1073/pnas.86.18.7067
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The phylogenetic relationships of 21 murine Antp-class (Drosophila mutation Antennapedia-type class) homeobox genes have been analyzed, and several groups of related genes have been identified. The murine Antp-class homeobox genes are localized within four gene clusters. The similar structural organization of the four gene clusters strongly suggests that genes within a group of related Antp-class homeobox genes are derived from duplications of large genomic regions. After the duplication, the gross structures of the homeobox gene clusters have been maintained over a long period of evolutionary time, indicating that the specific organization of genes within a cluster may be of functional importance.
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