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  • 标题:Mechanics of Frameshift Mutagenesis in Bacteriophage T4: Role of Chromosome Tips
  • 本地全文:下载
  • 作者:Dona M. Lindstrom ; John W. Drake
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1970
  • 卷号:65
  • 期号:3
  • 页码:617-624
  • DOI:10.1073/pnas.65.3.617
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:In contrast to observations in bacteria and fungi, frameshift mutations in bacteriophage T4 do not arise during genetic recombination. Nascent mutants, captured in the heterozygous condition, exhibit properties which indicate that the new lesions are located at the extreme tips of the chromosomes, and are segregated by a combination of recombination and replication.
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