期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：66
期号：4
页码：1199-1205
DOI：10.1073/pnas.66.4.1199
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：An electrostatic mechanism for force generation in muscle is proposed which does not require bond formation between thick and thin filaments nor movement of the cross bridges. The myosin heads, which project from the thick filaments and touch the thin filaments, possess a high negative surface charge density. Owing to their large dielectric increment, the thin filaments are polarized by the electric field generated by the myosin heads. The polarized thin filaments tend to move toward the center of the sarcomere. Myosin ATPase activity is increased in the overlap region to maintain the negative surface potential. Thus, ATP hydrolysis provides the energy for shortening. Calculations give estimated tensions generated by this model that are comparable to those observed experimentally for vertebrate striated muscle.
