标题：Conversion of Glycogen Phosphorylase b to a by Non-Activated Phosphorylase b Kinase: an In Vitro Model of the Mechanism of Increase in Phosphorylase a Activity with Muscle Contraction
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：67
期号：1
页码：345-350
DOI：10.1073/pnas.67.1.345
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Phosphorylase b kinase activity, as present in resting muscle in the non-activated form, appears to be ample to account for the fast appearance of phosphorylase a observed with muscle contraction. The kinase activity is repressed by free ATP and stimulated by free Mg2+. Phosphorylase b kinase activity increases greatly when the Mg2+:ATP ration exceeds 1. It is proposed that the breakdown of ATP that occurs during muscle contraction may represent the triggering factor for the observed in vivo conversion of phosphorylase b into a.
