期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：6
页码：1341-1345
DOI：10.1073/pnas.68.6.1341
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The structural basis for the A14 and A15 allotypic specificities of rabbit immunoglobulin G was investigated with Fe fragments prepared from homozygous rabbits. The presence of threonine in the C{gamma}2 region (position 309: Eu numbering) correlates with the A14 allotype; the presence of alanine at this same position correlates with the A15. Now that the sequence of the C{gamma}2 region of rabbit IgG has been completely elucidated, a high degree of homology of the constant region domains of rabbit and human {gamma} chains is apparent (about 60-80%).
关键词：column chromatography ; protein sequencing ; Fe ; tryptic peptides ; γ chains
