期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：7
页码：1547-1551
DOI：10.1073/pnas.68.7.1547
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Studies of the amino acid sequences around half-cystine residues in an immunoglobulin M have revealed an unexpectedly high number. At least 14 different sequences were found in the {micro} chain (VHIII subclass). Four of these were involved in interchain disulfide bridges and at least 10 in intrachain bridges. Five came from the {kappa} chain ({kappa}III subclass, Inv b). Several others, although having a high degree of homology, were not identical with those of either the {micro} or {kappa} chains. These results support the concept of an additional fragment in {gamma}M molecules, although its function and localization remain to be determined.
