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  • 标题:A Transition to a Compact Form of DNA in Polymer Solutions
  • 本地全文:下载
  • 作者:L. S. Lerman
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1971
  • 卷号:68
  • 期号:8
  • 页码:1886-1890
  • DOI:10.1073/pnas.68.8.1886
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:In the presence of over-threshold concentrations of simple neutral polymers and salts, DNA undergoes a cooperative change in its solution structure. Sedimentation studies at low DNA concentrations show that phage DNA molecules collapse into particles approaching the compactness of the contents of phage heads. The interaction between DNA and polymers is thought to be nonspecifically replusive.
  • 关键词:poly(vinyl pyrrolidinone) ; poly(ethylene oxide) ; T4 phage ; centrifugation
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