期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：9
页码：2006-2007
DOI：10.1073/pnas.68.9.2006
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Binding of [3H]acetylcholine (measured by equilibrium dialysis) to a particulate preparation of Torpedo electroplax exhibits autoinhibition at concentrations higher than 1 {micro}M. It is suggested that autoinhibition results from acetylcholine binding to regulatory sites on its receptor macromolecules. This binding causes the change to a new and inactive conformation and rejection of acetylcholine bound to the larger number of active sites. The relationship to the physiological phenomenon of desensitization is discussed.
