期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：9
页码：2293-2297
DOI：10.1073/pnas.68.9.2293
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A mechanism is proposed for the folding of protein chains. On the basis of short-range interactions, certain aminoacid sequences have a high propensity to be, say, [α]-helical. However, these short helical (or other ordered) regions can be stabilized only by long-range interactions arising from the proximity of two such ordered regions. These regions are brought near each other by the directing influence of certain other aminoacid sequences that have a high probability of forming {beta}-bends or variants thereof, also on the basis of short-range interactions. An analysis is made of the tendency of various amino acids to occur in {beta}-bends, and it is possible to predict the regions of a chain in which a {beta}-bend will occur with a high degree of reliability.
