期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：10
页码：2332-2335
DOI：10.1073/pnas.68.10.2332
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The specific activities of the succinate dehydrogenase-coenzyme Q10 reductase in gingival tissue from patients with periodontal disease have been compared with the corresponding specific activities of normal human periodontal tissue. The gingival biopsies from patients having diseased periodontal tissue showed a deficiency of coenzyme Q10, in contrast to those of the normal periodontal tissue which showed no deficiency. The presence or absence of a deficiency of coenzyme Q10 in the succinate-coenzyme Q10 enzyme system is appraised by determining the specific activity in the absence and again in the presence of exogenous coenzyme Q3. An increase in specific activity of this mitochondrial enzyme system in the presence of exogenous coenzyme Q3 reflects the mitochondrial deficiency of coenzyme Q10. Such increases ranged from 38-120% and averaged 81% for the individuals with periodontal disease, and were highly significant statistically. These data correlate with clinical studies in Japan that have indicated a therapeutic benefit of the administration of coenzyme Q7 to many patients with severe and destructive periodontal disease and with the benefit of administration of hexahydrocoenzyme Q4 to one such patient in the current work.
