期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：10
页码：2545-2548
DOI：10.1073/pnas.68.10.2545
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Phenolic products obtained on isomerization of the three arene oxides of toluene, the nine arene oxides of ortho-, meta-, and para-xylene, the arene oxide of mesitylene, and 2-methyl and 1,2-dimethylnaphthalene-1,2-oxides are compared to the phenolic products obtained by hepatic metabolism of the parent aromatic hydrocarbons. The results are compatible with the intermediacy of certain of these arene oxides in the metabolic pathway from hydrocarbons to phenols. Migrations of methyl groups as well as a remarkable apparent migration of oxygen are observed. The isomerization of 1,4-dimethylbenzene oxide to 2,4-dimethylphenol is analogous to the methyl migration observed in the enzymatic conversion of 4-methylphenylalanine to 3-methyltyrosine with phenylalanine hydroxylase. There are multiple pathways of isomerization of alkylarene oxides to phenols and they are determined by environmental and structural factors. The proportion and nature of products vary greatly with pH, which suggests the presence of different mechanisms for acid-catalyzed or spontaneous isomerizations of arene oxides.
