期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：11
页码：2818-2821
DOI：10.1073/pnas.68.11.2818
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 {+/-} 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection.
关键词：nucleocapsid ; viral envelope ; viral core ; DNA phosphate-group neutralization ; human carcinoma cells
