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  • 标题:Base Composition Differences between Avian Myeloblastosis Virus Transfer RNA and Transfer RNA Isolated from Host Cells
  • 本地全文:下载
  • 作者:Kurt Randerath ; Leonard J. Rosenthal ; Paul C. Zamecnik
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1971
  • 卷号:68
  • 期号:12
  • 页码:3233-3237
  • DOI:10.1073/pnas.68.12.3233
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Using a novel chemical tritium derivative method, we have determined the base composition of 4S RNA isolated from an RNA tumor virus, the avian myeloblastosis virus, and from normal and neoplastic host cells. Extensive differences were detected, particularly with respect to the amount of methylated bases in the viral RNA. The viral 4S RNA, which fulfills the criteria for designation as transfer RNA, appears to be derived from a precursor pool that is different from the precursor population of host-cell 4S RNA. These results are discussed in regard to the possible relationship between transfer RNA of avian mycoblastosis virus and cellular transfer RNA.
  • 关键词:isotope derivative method ; tritium fluorography
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