期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：1
页码：253-257
DOI：10.1073/pnas.69.1.253
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cytochalasin B reversibly causes extensive branching of myoblasts, fibroblasts, and nonencapsulated chondroblasts; it does not induce the formation of similar processes in myotubes, erythrocytes, amnion cells, encapsulated chondroblasts, or HeLa cells. The drug has no effect on the spontaneous contractions of isolated skeletal, cardiac, or smooth-muscle cells. Within 60 min, it depresses the incorporation of [14C]glucosamine into total mucopolysaccharide and glycoproteins by over 50%. The drug interferes with adhesion and sorting-out of dissociated embryonic cells. Cytochalasin B is likely to produce changes in components of the cell surface whose function is not readily or solely related to a system of "primitive contractile microfilaments."
