期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：4
页码：842-846
DOI：10.1073/pnas.69.4.842
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The decrease of the molecular size of poly(I{middle dot}C) to less than 106 decreases its ability to induce interferon, protect mice against virus, or enhance the immune response. Immune adjuvant activity appeared more sensitive to molecular weight than the other protective activities. The composition of the complex--the molecular size of the individual homopolymers when one was large and the other small--did not affect antiviral activity; the activity of a complex made from large poly(I) and small poly(C) was similar to one made from small poly(I) and large poly(C). Molecular size of the complex did not profoundly alter the side effects of poly(I{middle dot}C). At 2 mg/kg, none of the complexes markedly altered phagocytic function. Only the largest complex sensitized the mouse to endotoxin. However, all of the complexes studied profoundly inhibited drug metabolism by the liver microsomal enzymes between 24 and 72 hr after their inoculation. Decreasing the molecular weight did not alter this inhibition.
关键词：synthetic polynucleotide ; interferon ; antitumor agent ; drug metabolism
