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  • 标题:Activation of Leukemia Viruses by Graft-Versus-Host and Mixed Lymphocyte Reactions In Vitro
  • 本地全文:下载
  • 作者:M. S. Hirsch ; S. M. Phillips ; C. Solnik
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1972
  • 卷号:69
  • 期号:5
  • 页码:1069-1072
  • DOI:10.1073/pnas.69.5.1069
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Spleen cells from BALB/c or CAF1 mice released little or no detectable leukemia virus when cultured 2-7 days in vitro. In contrast, spleen cells of CAF1 mice previously inoculated with parental BALB/c spleen cells released leukemia viruses in 10 of 11 cases studied. Cultures of a mixture of spleen cells from normal BALB/c and CAF1 mice also contained leukemia viruses. Phytohemagglutinin induced the transformation of lymphocytes in cultures of CAF1 or BALB/c spleen cells, but this transformation did not activate leukemia viruses. It is concluded that mixed lymphocyte cultures in vitro, just as graft-versus-host reactions in vivo, can activate leukemia viruses that are normally present in a repressed form. This activation is not solely a function of lymphocyte transformation. The activated mouse leukemia virus may subsequently account for the observed high incidence of neoplasia in graft-versus-host disease.
  • 关键词:mice ; mitomycin C ; phytohemagglutinin
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