期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：5
页码：1141-1145
DOI：10.1073/pnas.69.5.1141
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Catecholamines bound covalently to glass beads have been found to have biological activity in several systems. Experimental evidence has been found that immobilized epinephrine and isoproterenol accelerate the heart rate in dogs, chick embryo, and chick heart cells grown in culture, whereas immobilized propranolol results in a decrease in heart rate. Isoproterenol bound to glass beads has also been shown to markedly increase the level of adenosine 3':5'-cyclic monophosphoric acid in glial cells. The effects of the immobilized catecholamines are of longer duration than when the compounds are administered in solution. The present data indicate that the compounds are exerting their action when bound to the beads.
