期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：5
页码：1287-1289
DOI：10.1073/pnas.69.5.1287
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Bacitracin is an inhibitor of the biosynthesis of squalene and sterols from mevalonic acid, C5-isopentenyl pyrophosphate, or C15-farnesyl pyrophosphate catalyzed by preparations from rat liver. The antibiotic is active at extremely low ratios of antibiotic to substrate. The mechanism of inhibition appears to be the formation of a complex between bacitracin, divalent cation, and C15-farnesyl pyrophosphate and other isoprenyl pyrophosphates. It is similar to the formation of the complex with C55-isopropenyl pyrophosphate in microbial systems. The toxicity of bacitracin for animal cells could be due in part to the formation of these complexes.
