期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：5
页码：1173-1175
DOI：10.1073/pnas.69.5.1173
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The discovery that methyl 3,3-dimethylglycidate rearranges to methyl levulinate on heating is discussed in terms of its possible consequences for the mechanism of action of the coenzyme B12-dependent enzymes: methylmalonyl-CoA mutase (EC 5.4.99.2 ), glutamate mutase (EC 5.4.99.1 ), and a-methyleneglutarate mutase. It is also suggested that the proposed mechanism may provide a unifying link between the mechanism of action of the above enzymes and that of the coenzyme B12-dependent dioldehydrase and related enzymes.
