期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：7
页码：1858-1862
DOI：10.1073/pnas.69.7.1858
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Immunological tolerance to a soluble, partially purified fraction of histocompatibility (H)-2a antigen was induced in B10.D2 strain mice. The fraction used was obtained after chromatography on a Sephadex G-150 column. Tolerance of humoral-antibody formation (cytotoxins and hemagglutinins) was observed in mice injected with soluble antigen since birth, but cell-mediated immunity, as measured by skin graft survival, remained intact. Tolerance was shown to be specific for H-2a antigens, since treated mice produced a regular humoral-antibody response to H-2b antigens. These findings, along with previous observations of the immunogenic and enhancing properties of our partially purified fraction, suggest that the solubilized antigen contains all the major determinants of H-2a antigens expressed on lymphoid-cell surfaces.
