期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：8
页码：2122-2124
DOI：10.1073/pnas.69.8.2122
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cobaltohemoglobin prepared from horse hemoglobin retains the full heterotropic linkage properties of the normal iron hemoglobin, including both the Bohr and phosphate effects. From this result, and the known connection between heterotropic linkage properties and hemoglobin conformational change, it is concluded that cobaltohemoglobin undergoes a quaternary structure transition upon oxygenation. Thus, the stereochemical changes that occur upon oxygen binding to cobalt, as well as to iron, must be compatible with the mechanism triggering such a transition.
