期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：9
页码：2377-2380
DOI：10.1073/pnas.69.9.2377
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Estrogen-induced morphologic differentiation of chick oviduct is accompanied by increases in the total endogenous mRNA activity of oviduct polysomes. Concomitant increases are also noted in ribosome translational capacity and activity of peptide chain initiation factors. Once the differentiation process nears completion (about 7 days of estrogen administration), total ribosomebound mRNA activity decreases, but the translational machinery remains very active. In addition, estrogen induces the accumulation of ovalbumin mRNA before ovalbumin is demonstrable in the oviduct. The data suggest that the rate-limiting event in the hormonal induction of cell-specific proteins, such as ovalbumin, is the synthesis and intracellular accumulation of specific mRNA for such proteins.
