期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：9
页码：2727-2731
DOI：10.1073/pnas.69.9.2727
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The major collagenous products synthesized in a cell-free polysome preparation are pro-[α]1 and pro-[α]2, formed in a ratio of 2:1. They are the precursor forms of [α]1 and [α]2 chains of normal connective-tissue collagen that are also formed in small amounts. A procollagen peptidase activity has been demonstrated in the supernatant fraction that can account for the formation of [α]1 and [α]2 chains from their precursors. The polysomal system is activated by a salt extract of reticulocyte ribosomes and is inhibited by aurintricarboxylic acid, suggesting that the polysomes are able to initiate protein synthesis.
关键词：collagen ; protein synthesis ; mRNA ; initiation factors
