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  • 标题:A Genetic Locus for Inducibility of C-Type Virus in BALB/c Cells: The Effect of a Nonlinked Regulatory Gene on Detection of Virus after Chemical Activation
  • 本地全文:下载
  • 作者:John R. Stephenson ; Stuart A. Aaronson
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1972
  • 卷号:69
  • 期号:10
  • 页码:2798-2801
  • DOI:10.1073/pnas.69.10.2798
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Previous studies have shown that chemicals can transiently activate endogenous C-type viruses from embryo cells of the BALB/c mouse strain, but not from cells of another mouse strain, NIH Swiss. The number of genetic loci for inducibility of endogenous virus in BALB/c cells was investigated with cell lines derived from appropriate, F1, F2-hybrid, and backcross generation embryos of these strains. A single genetic locus responsible for inducibility of virus in BALB/c cells was detected, and tentatively designated Ind. A second locus, previously described in studies of mouse-cell susceptibility to exogenous virus infection, Fv-1, was found to be genetically nonlinked to Ind. This regulatory gene plays an important role in determining whether the induced viruses of BALB/c cells can persist after chemical activation.
  • 关键词:mouse embryo ; endogenous virus ; IdU
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