期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：10
页码：2842-2845
DOI：10.1073/pnas.69.10.2842
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：E. coli cells initiating chromosome replication after release from amino-acid starvation were incubated in [3H]thymine of moderate specific activity, followed by incubation in [3H]thymine plus [3H]thymidine of very high specific activity. The grain tracks produced in autoradiographs of chromosomes were denser on both ends than in the middle. The autoradiographic patterns are, therefore, evidence that replication of the chromosome in E. coli is bidirectional.
