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  • 标题:Configuration of the C(20) Epimer of 7,8-Dihydrobatrachotoxinin A
  • 本地全文:下载
  • 作者:Isabella L. Karle
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1972
  • 卷号:69
  • 期号:10
  • 页码:2932-2936
  • DOI:10.1073/pnas.69.10.2932
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:7,8-Dihydrobatrachotoxinin A is an intermediate in the synthesis of batrachotoxin, the extremely potent venom from the Colombian frog Phyllobates aurotaenia. A crystal structure analysis by x-ray diffraction has confirmed that the intermediate is identical with the natural batrachotoxinin A except for the saturation of the C(7)-C(8) bond. There are seven asymmetric carbon atoms in the molecule. The cis A/B and C/D ring junctions cause the molecule to assume the characteristic shape of cardioactive steroids. A cage is formed from the A-ring, atom C(9), and the O atom that makes the ether linkage between C(3) and C(9).
  • 关键词:x-ray crystallography ; frog ; venom ; Phyllobates ; cardioactive steroid
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