期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：10
页码：2914-2917
DOI：10.1073/pnas.69.10.2914
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The amino-acid sequence of human {beta}2-microglobulin, a protein of 100 residues, is related to parts of the constant region of IgG heavy chain. The dog homologue of human {beta}2-microglobulin has now been isolated and its amino-acid sequence has been partially determined. The two proteins (human and dog {beta}2-microglobulins) are demonstrably different at only 6 or 7 of the 42 positions examined. Use of the dog should permit experimental investigation of the functional relationships of {beta}2-microglobulin to immunoglobulins and the immune system. {beta}2-Microglobulin has also been detected in serum from a chimpanzee. The gene for {beta}2-microglobulin may correspond to the end portion of an immunoglobulin heavy chain gene.
