期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：12
页码：3673-3676
DOI：10.1073/pnas.69.12.3673
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The aminoacid sequence of the "hinge" region of two human IgA1 myeloma proteins was found to be identical. A 30-residue fragment contains 3 cysteines, 12 prolines, and carbohydrate, and the sequence of a small segment of the hinge region is repeated at least twice. Since a deletion of 12-13 residues was found in the same region of an IgA2 myeloma protein, it is possible that IgA1 molecules are the result of the insertion of a partially duplicated gene segment in the immunoglobulin genes.
