期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：12
页码：3825-3827
DOI：10.1073/pnas.69.12.3825
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Five protease inhibitors with different modes of action were found to reduce the growth of transformed mouse (Py3T3, SV3T3, and 3T12) and hamster (PyBHK) cells. Some of these inhibitors caused the transformed cells to cease growth at saturation densities characteristic for nontransformed cells. The protease inhibitors were strikingly selective with regard to the transformed cells; they had essentially no effect on the growth of the nontransformed cells. From this result, it is concluded that the inhibitors block a protease-like activity that is required for the unrestrained growth of transformed cells. The inhibitors exerted their effect directly on the cells; they did not affect growth by interacting with serum components of the medium.
