期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：1
页码：235-239
DOI：10.1073/pnas.70.1.235
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The idiotype of the mouse myeloma protein with anti-[α]-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with [α]1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.
关键词：radioimmunoassay ; hapten ; light and heavy chains ; mice
