期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：2
页码：343-346
DOI：10.1073/pnas.70.2.343
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cells from a myeloid leukemic line in culture can be induced by the differentiation-inducing protein MGI to form colonies with normal differentiation to mature macrophages and granulocytes. This line consisted of clones that can be induced to undergo normal cell differentiation (D+ clones) and clones (D- clones) that were not inducible. D+ clones were able to undergo differentiation to both macrophages and granulocytes. Normal differentiation was induced even in clones that were no longer diploid. D+ clones can segregate some D- progeny, and D- clones can segregate some D+ progeny. This, therefore, provides a system for studies on the genetic and chemical control of cell differentiation in leukemic cells.
关键词：mice ; chromosome number ; differentiation-inducing protein
