期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：3
页码：834-838
DOI：10.1073/pnas.70.3.834
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The mouse thymus contains cells that synthesize and secrete minute amounts of immunoglobulin (Ig). These cells were studied by a combination of cytotoxic tests (with alloantisera prepared in congenic strains of mice) followed by pulse labeling of the surviving cell population with [3H]tyrosine. The immunoglobulin-synthesizing cells constitute less than 2% of the total cell population and are [theta] -, TL-, Ly-B-, Ig+, H-2+, and PC+. Since this phenotype is not characteristic of cells of the thymocyte lineage, the Ig+ cells are probably plasma cells and/or bone marrow-derived (B) lymphocytes. Similar studies of spleen cells indicate that immunoglobulin-synthesizing and secreting cells are [theta] -.
