期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：3
页码：769-772
DOI：10.1073/pnas.70.3.769
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A specific and sensitive assay for phenylethanolamine in tissues is described. By this assay, phenylethanolamine was detected in many peripheral tissues and brains of rats. It is unequally distributed in rat brain, with the highest concentration present in hypothalamus and midbrain. Concentrations of brain phenylethanolamine were elevated after administration of phenylethylamine, phenylalanine, p-chlorophenylalanine, and monoamine oxidase inhibitors and decreased after administration of dopamine-{beta} -hydroxylase inhibitors. Denervation of sympathetic nerves caused a moderate fall in phenylethanolamine concentrations. These results indicate that phenylethanolamine is synthesized intraneuronally from phenylalanine and phenylethylamine, but that only part of the phenylethanolamine is stored in sympathetic nerves.
关键词：enzyme assay ; intraneural synthesis and storage ; phenylethylamine ; phenylalanine ; rat
