期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：4
页码：1246-1249
DOI：10.1073/pnas.70.4.1246
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Proton nuclear magnetic resonance spectra of normal and des-(his 146{beta}) human hemoglobin in the aromatic resonance region have been compared at different pH values. From these measurements, a pK value for histidine 146{beta} of 7.1 in carbonmonoxyhemoglobin and 8.0 in deoxyhemoglobin has been found. These pK values confirm the proposed role of histidine 146{beta} in the alkaline Bohr effect.
