期刊名称:Proceedings of the National Academy of Sciences
印刷版ISSN:0027-8424
电子版ISSN:1091-6490
出版年度:1973
卷号:70
期号:4
页码:1268-1272
DOI:10.1073/pnas.70.4.1268
语种:English
出版社:The National Academy of Sciences of the United States of America
摘要:The inducibility of tyrosine aminotransferase (EC 2.6.1.5 ) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49 ) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8 ) and, therefore, can be assigned to the X chromosome.