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  • 标题:Human Regulatory Gene for Inducible Tyrosine Aminotransferase in Rat-Human Hybrids
  • 本地全文:下载
  • 作者:Carlo M. Croce ; Gerald Litwack ; Hilary Koprowski
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1973
  • 卷号:70
  • 期号:4
  • 页码:1268-1272
  • DOI:10.1073/pnas.70.4.1268
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The inducibility of tyrosine aminotransferase (EC 2.6.1.5 ) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49 ) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8 ) and, therefore, can be assigned to the X chromosome.
  • 关键词:enzyme induction ; dexamethasone receptor ; X chromosome ; X-linked isozymes
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