期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：5
页码：1313-1315
DOI：10.1073/pnas.70.5.1313
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Incubation of HbS (or HbA) with aspirin leads to incorporation of acetyl groups into the protein. Incorporation was followed by the use of aspirin labeled with 14C in the acetyl group. The acetylated hemoglobins show an increase in oxygen affinity compared to the parent proteins. If acetylation also occurs in vivo, administration of aspirin might ameliorate the severity of sickle cell disease.
