标题：Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：5
页码：1564-1568
DOI：10.1073/pnas.70.5.1564
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The nucleotides ppGpp and pppGpp accumulate when wild-type, but not rel-, strains of Escherichia coli are starved for required amino acids. These compounds are synthesized on ribosomes, in the presence of the product of the rel gene, from GDP and GTP; ATP is used as the phosphate donor. The signal for making these compounds is the presence of an uncharged tRNA in the ribosomal acceptor site. These compounds are not accumulated if the ribosomes are actively engaged in protein synthesis.
关键词：stringent control ; ppGpp (MSI) and pppGpp (MSII) ; protein synthesis ; Escherichia coli
