期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：7
页码：2003-2005
DOI：10.1073/pnas.70.7.2003
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：71 Mutants of Dictyostelium purpureum, unable to carry out normal development, were isolated. These mutants fall into three phenotypic classes. The mutants of the first class do not aggregate. Those of the second class develop a little further and form conical aggregates. The mutants of the third class progress still further, and the conical aggregates are transformed into finger-shaped masses, but no fruiting bodies are formed. Mutants of each class were able to form fruiting bodies when mixed with mutants of other classes. Pairs of mutants belonging to the same class, however, never responded synergistically. This result indicates the presence of three distinct developmental stages in the process of the fruiting-body formation. Experiments with actinomycin D suggested that genes controlling the developmental process of D. purpureum were divided into three groups which were identical to those identified by the analysis of synergism.
