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  • 标题:Discrimination between Messenger Ribonucleic Acids by a Mammalian Translation Initiation Factor
  • 本地全文:下载
  • 作者:U. Nudel ; B. Lebleu ; M. Revel
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1973
  • 卷号:70
  • 期号:7
  • 页码:2139-2144
  • DOI:10.1073/pnas.70.7.2139
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:A factor from rabbit-reticulocyte ribosome, which stimulates by 5-fold initiation of hemoglobin mRNA translation in Krebs ascites cell extracts, was purified to homogeneity. The factor, a protein of about 65,000 molecular weight in sodium dodecyl sulfate, discriminates between various mRNAs: it stimulates translation of [α] globin mRNA and of tobacco mosaic virus RNA, but has only a small effect on {beta} globin mRNA and no effect at all on Mengo virus RNA translation.
  • 关键词:reticulocyte initiation factors ; hemoglobin synthesis ; Krebs ascites extracts
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