期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：8
页码：2229-2233
DOI：10.1073/pnas.70.8.2229
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Monoiodoamphenicol, a synthetic analogue of chloramphenicol, has been shown by competition experiments with chloramphenicol and lincomycin to bind at the same site of 70S ribosomes as chloramphenicol. At -- 2{degrees} it forms a 1:1 complex with 70S ribosomes having a value of K (7.5 x 104 M-1) that is one order of magnitude lower than that of chloramphenicol. At 37{degrees
